Rubens was born in the German town of Siegen, in Westphalia. His father, Jan Rubens, a lawyer and alderman of Antwerp, had fled the Spanish Netherlands (present-day Belgium) in 1568 with his wife, Maria Pypelinckx, and four children to escape religious persecution for his Calvinist beliefs. Religion figured prominently in much of his work, and Rubens later became one of the leading voices of the Catholic Counter-Reformation style of painting[7] (he had said "My passion comes from the heavens, not from earthly musings").

After Jan’s death in 1587, the family returned to Antwerp, where young Peter Paul, raised in his mother’s Roman Catholic faith, received a Classical education. His artistic training began in 1591 with his apprenticeship to Tobias Verhaecht, a kinsman and landscape painter of modest talent. A year later he moved on to the studio of Adam van Noort, where he remained for four years until being apprenticed to Antwerp’s leading artist, Otto van Veen, dean of the painters’ guild of St. Luke. Van Veen imbued Rubens with a lively sense of painting as a lofty humanistic profession.

In 1600 Rubens traveled to Italy. He stopped first in Venice, where he saw paintings by Titian Vecellio, Veronese, and Tintoretto, before settling in Mantua at the court of Duke Vincenzo I Gonzaga. The colouring and compositions of Veronese and Tintoretto had an immediate effect on Rubens's painting, and his later, mature style was profoundly influenced by Titian. With financial support from the Duke, Rubens travelled to Rome by way of Florence in 1601. There, he studied classical Greek and Roman art and copied works of the Italian masters. The Hellenistic sculpture Laocoön and His Sons was especially influential on him, as was the art of Michelangelo, Raphael, and Leonardo da Vinci. He was also influenced by the recent, highly naturalistic paintings by Caravaggio.

Rubens later made a copy of Caravaggio's Entombment of Christ and recommended his patron, the Duke of Mantua, to purchase The Death of the Virgin (Louvre). After his return to Antwerp he was instrumental in the acquisition of The Madonna of the Rosary (Kunsthistorisches Museum, Vienna) for the St. Paul's Church in Antwerp. During this first stay in Rome, Rubens completed his first altarpiece commission, St. Helena with the True Cross for the Roman church of Santa Croce in Gerusalemme.

Rubens travelled to Spain on a diplomatic mission in 1603, delivering gifts from the Gonzagas to the court of Philip III. While there, he studied the extensive collections of Raphael and Titian that had been collected by Philip II. He also painted an Equestrian portrait of the Duke of Lerma during his stay (Prado, Madrid) that demonstrates the influence of works like Titian's Charles V at Mühlberg (1548; Prado, Madrid). This journey marked the first of many during his career that combined art and diplomacy.

He returned to Italy in 1604, where he remained for the next four years, first in Mantua and then in Genoa and Rome. In Genoa, Rubens painted numerous portraits, such as the Marchesa Brigida Spinola-Doria (National Gallery of Art, Washington, D.C.), and the portrait of Maria di Antonio Serra Pallavicini in a style that influenced later paintings by Anthony van Dyck, Joshua Reynolds and Thomas Gainsborough. Rubens's experiences in Italy continued to influence his work. He continued to write many of his letters and correspondences in Italian, signed his name as "Pietro Paolo Rubens", and spoke longingly of returning to the peninsula—a hope that never materialized. Rubens's experiences in Italy continued to influence his work. He continued to write many of his letters and correspondences in Italian, signed his name as "Pietro Paolo Rubens", and spoke longingly of returning to the peninsula—a hope that never materialized.

In October 1608, having received news that his mother was gravely ill, Rubens rushed home to Antwerp—but too late. Yet despite his personal loss, his arrival was otherwise timely. His return coincided with a period of renewed prosperity in the city with the signing of the Treaty of Antwerp in April 1609, which initiated the Twelve Years' Truce. In September 1609 Rubens was appointed as court painter by Albert VII, Archduke of Austria, and Infanta Isabella Clara Eugenia of Spain, sovereigns of the Low Countries.

He received special permission to base his studio in Antwerp instead of at their court in Brussels, and to also work for other clients. He remained close to the Archduchess Isabella until her death in 1633, and was called upon not only as a painter but also as an ambassador and diplomat. Rubens further cemented his ties to the city when, on 3 October 1609, he married Isabella Brant, the daughter of a leading Antwerp citizen and humanist, Jan Brant, he celebrated their happy union in his Double Portrait in a Honeysuckle Bower (1609–10). Rubens was commissioned to paint for the Antwerp Town Hall a celebratory Adoration of the Magi (1609), which quickly established his fame at home.

The Twelve Years’ Truce prompted a major refurbishing of Flemish churches. The first of Rubens’s two great Antwerp triptychs, The Raising of the Cross (1610–11), combined Italianate reflections of Tintoretto and Caravaggio with Flemish realism in a heroic affirmation of redemptive suffering. His second triptych for Antwerp’s cathedral, The Descent from the Cross (1611–14), is more Classical and restrained in keeping with its subject. This work reflected Rubens’s vigorous renewal of the early Netherlandish tradition of Jan van Eyck, Hans Memling, and Rogier van der Weyden. Its widespread fame was ensured by the publication of an engraving; among its future admirers was the young Rembrandt.

The decade from 1610 to 1620 witnessed an enormous production of altarpieces for Roman Catholic churches—powerful, emotive images of Christ, the Virgin Mary, and the saints—as Rubens became the chief artistic proponent of Counter-Reformation spirituality in northern Europe. Among his more important religious compositions from this period are The Last Judgment(c. 1616) and Christ on the Cross (also called Le Coup de Lance, 1620). Yet during this same decade Rubens also produced many paintings on secular themes—mythological, historical, and allegorical subjects, hunting scenes, and portraits. Among the finest of his mythological paintings is the Rape of the Daughters of Leucippus (c. 1617–18), while The Hippopotamus Hunt (c. 1615–16) typifies his vision of wild animal hunts.

In 1621, the Queen Mother of France, Marie de' Medici, commissioned Rubens to paint two large allegorical cycles celebrating her life and the life of her late husband, Henry IV, for the Luxembourg Palace in Paris. The Marie de' Medici cycle (now in the Louvre) was installed in 1625, and although he began work on the second series it was never completed. After the end of the Twelve Years' Truce in 1621, the Spanish Habsburg rulers entrusted Rubens with a number of diplomatic missions. While in Paris in 1622 to discuss the Marie de' Medici cycle, Rubens engaged in clandestine information gathering activities, which at the time was an important task of diplomats.

Between 1627 and 1630, Rubens's diplomatic career was particularly active, and he moved between the courts of Spain and England in an attempt to bring peace between the Spanish Netherlands and the United Provinces. He also made several trips to the northern Netherlands as both an artist and a diplomat. Rubens was in Madrid for eight months in 1628–1629. In addition to diplomatic negotiations, he executed several important works for Philip IV and private patrons. He also began a renewed study of Titian's paintings, copying numerous works including the Madrid Fall of Man (1628–29). During this stay, he befriended the court painter Diego Velázquez and the two planned to travel to Italy together the following year. Rubens, however, returned to Antwerp and Velázquez made the journey without him.

His stay in Antwerp was brief, and he soon travelled on to London where he remained until April 1630. An important work from this period is the Allegory of Peace and War (1629; National Gallery, London). It illustrates the artist's lively concern for peace, and was given to Charles I as a gift.

While Rubens's international reputation with collectors and nobility abroad continued to grow during this decade, he and his workshop also continued to paint monumental paintings for local patrons in Antwerp. The Assumption of the Virgin Mary (1625–6) for the Cathedral of Antwerp is one prominent example.

In 1630, four years after the death of his first wife Isabella, the 53-year-old painter married his first wife's niece, the 16-year-old Hélène Fourment. Hélène inspired the voluptuous figures in many of his paintings from the 1630s, including The Feast of Venus (Kunsthistorisches Museum, Vienna), The Three Graces and The Judgement of Paris (both Prado, Madrid).

In 1635, Rubens bought an estate outside Antwerp, the Steen, where he spent much of his time. Landscapes, such as his Château de Steen with Hunter (National Gallery, London) and Farmers Returning from the Fields(Pitti Gallery, Florence), Landscape with a Rainbow (1636) and its pendant Landscape with Het Steen (1636), reflect the more personal nature of many of his later works. He also drew upon the Netherlandish traditions of Pieter Bruegel the Elder for inspiration in later works like Flemish Kermis (c. 1630; Louvre, Paris).

Despite frequent incapacitating attacks of “gout” (which was probably arthritis), Rubens continued to accept a wide range of commissions. In 1638 he designed a triumphal carriage, or parade “float,” in the form of a ship to celebrate the Spanish naval victory over the Dutch forces at Calloo. Yet his personal view of war remained deeply pessimistic, as revealed in his painting The Horrors of War (1637), a precursor of Picasso’s Guernica.

Rubens died from heart failure as a result of his chronic gout on 30 May 1640. He was interred in the Saint James' Church in Antwerp.

The art of Peter Paul Rubens is a fusion of the traditions of Flemish realism with the Classicizing tendencies of the Italian Renaissance. Rubens was able to infuse his own astounding vitality into a powerful and exuberant style that came to epitomize the Baroque art of the 17th century. The ample, robust, and opulent figures in his paintings generate a pervasive sense of movement in vivid, dynamic compositions. Rubens was one of the most assimilative, versatile, and productive of all Western artists, and his almost limitless resources of invention enabled him to become the master of the greatest studio organization in Europe since that of Raphael in Rome a century before. The larger the scale of the undertaking, the more congenial it was to his spirit. Rubens’s recurrent impact on artists was almost as universal as the talents of the man himself. Painter, diplomat, impresario, scholar, antiquarian, architect, humanist—Rubens embodied the Baroque fulfillment of the Renaissance man.

At a Sotheby's auction on 10 July 2002, Rubens's painting Massacre of the Innocents, rediscovered not long before, sold for £49.5 million (US$76.2 million) to Lord Thomson. At the end of 2013 this remained the record auction price for an Old Master painting. At a Christie's auction in 2012, Portrait of a Commander sold for £9.1 million (US$13.5 million) despite a dispute over the authenticity so that Sotheby's refused to auction it as a Rubens.